Product Name :
27-Hydroxycholesterol (CAS 20380-11-4)
Synonym :
27-Hydroxycholesterol is also known as 25(R)-27-hydroxy Cholesterol.
Application :
27-Hydroxycholesterol is an oxysterol with cholesterol oxidation metabolite properties and a selective estrogen receptor modulator.
CAS:
20380-11-4
Purity:
Molecular Weight:
402.65
Formula :
C27H46O2
Physical state:
Solid
solubility :
Soluble in chloroform. Insoluble in water.
Shipping Condition :
Store at room temperature
Melting point:
194.53° C (Predicted)
SMILES:
C[C@H](CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)CO
References:
:The oxysterol 27-hydroxycholesterol increases beta -amyloid and oxidative stress in retinal pigment epithelial cells.1530793-63-5 Price | Dasari, B., et al. 2010. BMC Ophthalmol. 10: 22. PMID: 20836858Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. | Karuna, R., et al. 2011. Atherosclerosis. 214: 448-55. PMID: 21130455Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer′s disease. | Mateos, L., et al. 2011. J Alzheimers Dis. 24: 669-79. PMID: 2129725427-Hydroxycholesterol: the first identified endogenous SERM. | Umetani, M. and Shaul, PW. 2011. Trends Endocrinol Metab. 22: 130-5. PMID: 2135359327-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. | Nelson, ER., et al. 2013. Science. 342: 1094-8. PMID: 2428833227-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer.1219741-19-1 supplier | Marwarha, G., et al. 2017. Chem Phys Lipids. 207: 108-126. PMID: 2858343427-Hydroxycholesterol, an endogenous selective estrogen receptor modulator. | He, S. and Nelson, ER. 2017. Maturitas. 104: 29-35. PMID: 2892317427-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells. | Chen, S., et al. 2019. Front Mol Neurosci. 12: 14. PMID: 3088128527-Hydroxycholesterol contributes to cognitive deficits in APP/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction.PMID:33390058 | Wang, Y., et al. 2020. J Neuroinflammation. 17: 199. PMID: 3259330627-Hydroxycholesterol, The Estrogen Receptor Modulator, Alters DNA Methylation in Breast Cancer. | Vini, R., et al. 2022. Front Endocrinol (Lausanne). 13: 783823. PMID: 3536007027-hydroxycholesterol linked high cholesterol diet to lung adenocarcinoma metastasis. | Li, X., et al. 2022. Oncogene. 41: 2685-2695. PMID: 3537992427-Hydroxycholesterol promotes metastasis by SULT2A1-dependent alteration in hepatocellular carcinoma. | He, T., et al. 2022. Cancer Sci. 113: 2575-2589. PMID: 35599597The emerging role of 27-hydroxycholesterol in cancer development and progression: An update. | Abdalkareem Jasim, S., et al. 2022. Int Immunopharmacol. 110: 109074. PMID: 35978522